Tuesday, December 13, 2011
Monday, November 7, 2011
CALORIE INTAKE MIMETICS / CALORIE RESTRICTION MIMETICS
As per wikipedia :- Caloric restriction (CR), or calorie restriction, is a dietary regimen that restricts calorie intake, where the baseline for the restriction varies, usually being the previous, unrestricted, intake of the subjects. Calorie restriction without malnutrition[ has been shown to improve age-related health and to slow the ageing process in a wide range of animals and some fungi.
It has been found that low calorie intake is somewhat related to longevity because it helps to improve certain biomarkers of ageing.
As studies over the past two decades defined the beneficial biochemical and physiological effects of calorie restriction, scientists found that a variety of substances, both drugs and natural compounds, could mimic these desirable effects. These so-called “calorie restriction mimetics” have great potential clinical value because very few people can adhere to the degree of calorie restriction that will lead to substantial extension of life.
A calorie restriction mimetic is a pharmaceutical or natural compound which has the ability to reproduce one or more principal biological effects of calorie restriction. There are many putative calorie restriction mimetics that are potentially useful in humans.
They mainly act by affecting the glucose metabolism by interfering with the production of glucose in the body so that cells consume it less and produce less free radicals which are responsible for ageing . There are various hypothesis as to how they work but ultimate aim of these drugs is truncating the levels of free radicals.
Example :
1) Resveratrol :-A natural phenol produced by many plantswhen attacked by pathogens like bacteria and fungi
2) 2- Deoxy glucose - is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis and trapped by hexokinase
It has been found that low calorie intake is somewhat related to longevity because it helps to improve certain biomarkers of ageing.
As studies over the past two decades defined the beneficial biochemical and physiological effects of calorie restriction, scientists found that a variety of substances, both drugs and natural compounds, could mimic these desirable effects. These so-called “calorie restriction mimetics” have great potential clinical value because very few people can adhere to the degree of calorie restriction that will lead to substantial extension of life.
A calorie restriction mimetic is a pharmaceutical or natural compound which has the ability to reproduce one or more principal biological effects of calorie restriction. There are many putative calorie restriction mimetics that are potentially useful in humans.
They mainly act by affecting the glucose metabolism by interfering with the production of glucose in the body so that cells consume it less and produce less free radicals which are responsible for ageing . There are various hypothesis as to how they work but ultimate aim of these drugs is truncating the levels of free radicals.
Example :
 |
| 2- Deoxy glucose |
2) 2- Deoxy glucose - is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis and trapped by hexokinase
Thursday, May 5, 2011
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